Alacris Theranostics GmbH — a leader in innovative molecular diagnostics, specialising in personalised oncology, combining next-generation sequencing (NGS), advanced bioinformatics, and systems biology to transform scientific insights into enhanced cancer diagnostics and more precise treatment decisions, collaborating with leading research institutions, hospitals, and pharmaceutical partners — is seeking an experienced Bioinformatician / Computational Biologist / NGS Data Analyst for its multidisciplinary team in Berlin, Germany. This is a 2-year initial appointment with extension possibility and immediate start, focused on processing and analysing NGS datasets — including RNA-Seq, WES, WGS, and single-cell sequencing — from tumour samples. Excellent R and Python programming skills, proven NGS data analysis expertise, and a solid foundation in human molecular genetics are required. Reference number: ALA-NGSA-0426. Applications close 15 April 2026.
About Alacris Theranostics GmbH — Personalised Molecular Oncology | Berlin
Company: Alacris Theranostics GmbH — Leader in innovative molecular diagnostics, personalised oncology | Berlin, Germany
Technology: Next-Generation Sequencing (NGS) · Advanced Bioinformatics · Systems Biology — transforming scientific insights into enhanced cancer diagnostics and more precise treatment decisions
Partners: Leading research institutions · Hospitals · Pharmaceutical partners — collaborative, impact-focused oncology diagnostics ecosystem
Team: Multidisciplinary team of bioinformaticians, molecular biologists, and software engineers — dedicated to developing innovative analysis pipelines and diagnostic solutions in oncology
How to Apply: Single PDF with CV, publication list, research/work experience details, and three referee contacts | Cite ref: ALA-NGSA-0426 | Deadline: 15 April 2026
What Alacris Theranostics Offers
Role: Rewarding and challenging position within a dynamic biotech company based in the vibrant city of Berlin
Salary: Competitive salary commensurate with qualifications and experience in the Berlin biotech and bioinformatics market
Contract: 2-year initial term with possibility of extension — full-time, immediately available start
Team: Multidisciplinary environment with bioinformaticians, molecular biologists, and software engineers developing cutting-edge NGS analysis pipelines and oncology diagnostic solutions
Impact: Direct contribution to improved cancer patient outcomes — working at the clinical and scientific interface where bioinformatics makes a measurable difference to treatment decision precision
Berlin: Vibrant scientific city with an extraordinary biotech, research, and life sciences ecosystem — combining world-class research institutions (Charité, MDC, BIH, DKFZ Berlin) with an exceptional quality of life
Why This Alacris Theranostics NGS Bioinformatics Role Is a Career-Defining Opportunity in 2026
Precision Oncology at the Clinical Frontier: Developing NGS analysis pipelines for tumour samples that directly inform cancer treatment decisions — at a company where bioinformatics output shapes real patient therapy choices — provides the most clinically meaningful and professionally consequential application context available to computational biologists and bioinformaticians in the life sciences sector
Comprehensive NGS Modality Exposure: Working across RNA-Seq, WES, WGS, and single-cell sequencing from tumour samples within a single role provides a breadth of NGS data type experience that most academic or single-modality industry positions cannot match — building the comprehensive NGS bioinformatics capability that is among the most commercially valued in the global cancer genomics market
Systems Biology + Cancer Genomics: Alacris Theranostics’s combination of NGS, bioinformatics, and systems biology creates an intellectually distinctive analytical environment that goes beyond standard variant calling pipelines into the more complex territory of integrating multi-omic data for personalised treatment prediction — the frontier of precision oncology bioinformatics
Berlin Biotech Ecosystem: Berlin’s extraordinary concentration of life sciences research institutions, biotech companies, and clinical partners creates an exceptional professional network environment for computational oncology researchers at any career stage
Position Overview — NGS Data Analyst / Bioinformatician, Molecular Oncology
This NGS Data Analyst / Bioinformatician role at Alacris Theranostics GmbH in Berlin is a full-time, 2-year initial appointment focused on processing and analysing next-generation sequencing datasets derived from tumour samples, contributing to the development of innovative analysis pipelines and diagnostic solutions in molecular oncology. Working within a multidisciplinary team of bioinformaticians, molecular biologists, and software engineers, you will process and analyse NGS datasets including RNA-Seq (bulk and single-cell), whole-exome sequencing (WES), whole-genome sequencing (WGS), and single-cell sequencing from tumour samples; develop and maintain NGS analysis pipelines; apply statistical and high-dimensional data analysis methods to cancer genomics data; contribute to the translation of bioinformatics insights into diagnostically actionable findings; and collaborate with molecular biologists, clinical partners, and software engineers to develop and improve Alacris Theranostics’s personalised oncology diagnostic solutions. The role requires excellent R and Python programming skills, proven NGS data analysis expertise, solid human molecular genetics foundations, knowledge of statistics and high-dimensional data analysis, and a genuine interest in precision oncology.
Why This Alacris Theranostics NGS Data Analyst Role Is the Computational Oncology Career of 2026 in Berlin: Bioinformaticians and computational biologists with excellent R and Python programming skills, proven NGS data analysis experience spanning multiple sequencing modalities (RNA-Seq, WES, WGS, single-cell), solid human molecular genetics foundations, statistics and high-dimensional data analysis proficiency, genuine precision oncology interest, and the collaborative communication skills to work effectively in a multidisciplinary clinical-scientific team — have an outstanding opportunity at Alacris Theranostics to work on some of the most clinically meaningful and scientifically stimulating NGS data analysis challenges available in the European cancer genomics and personalised medicine sector. Applications close 15 April 2026 — apply immediately to ensure your application is considered before the deadline.
Key Responsibilities
NGS Data Processing & Analysis — Tumour Samples Across Multiple Modalities
- Process and analyse RNA-Seq datasets from tumour samples — applying the complete bulk RNA-Seq analysis workflow including quality control (FastQC, MultiQC, Trim Galore), read alignment (STAR, HISAT2, or equivalent), expression quantification (HTSeq, featureCounts, Salmon, Kallisto), differential expression analysis (DESeq2, edgeR, limma-voom), gene set enrichment analysis (GSEA, fgsea), and the specific interpretation of tumour transcriptome data in the context of oncogenic pathway activity, tumour immune microenvironment characterization, and treatment response prediction in personalised oncology diagnostics
- Process and analyse Whole-Exome Sequencing (WES) data from tumour samples — executing the clinical WES analysis pipeline from FASTQ quality control through alignment (BWA-MEM or equivalent), duplicate marking, base quality score recalibration, somatic variant calling (Mutect2, Strelka2, or equivalent), variant annotation (VEP, Annovar), tumour mutational burden (TMB) calculation, microsatellite instability (MSI) assessment, copy number variation (CNV) analysis (GATK4 CNV, PureCN, FACETS), and neoantigen prediction — producing the comprehensive mutational landscape characterizations that inform personalised treatment strategy at Alacris Theranostics
- Process and analyse Whole-Genome Sequencing (WGS) data from tumour samples — extending WES analytical capabilities to the full genome context including structural variant detection (DELLY, LUMPY, Manta), comprehensive copy number analysis, mutational signature analysis (MutationalPatterns, SigProfiler), chromatin accessibility assessment where relevant, and the integrative WGS data interpretation that provides the most comprehensive genomic characterization of individual tumours for personalised oncology application
- Process and analyse single-cell sequencing data from tumour samples — applying single-cell RNA-Seq analysis workflows (Cell Ranger, Seurat, Scanpy) for tumour heterogeneity characterization, cell type deconvolution, trajectory analysis, and the specific single-cell analytical approaches that reveal the clonal structure, cellular composition, and transcriptional diversity of individual tumours in ways that bulk sequencing cannot capture, contributing to Alacris Theranostics’s precision oncology diagnostic capability at the single-cell resolution level
Pipeline Development, Statistical Analysis & Systems Biology Integration
- Develop and maintain NGS analysis pipelines in R and Python — building the reproducible, version-controlled, documented, and computationally efficient bioinformatics pipelines (using Nextflow, Snakemake, or equivalent workflow managers) that process tumour NGS datasets consistently, at scale, and to the quality standards that clinical oncology diagnostics require, applying software engineering best practices (modular code architecture, unit testing, documentation, containerization with Docker/Singularity) that make pipelines maintainable and deployable across different computational environments
- Apply statistics and high-dimensional data analysis to cancer genomics data — using the appropriate statistical methods (survival analysis, multiple testing correction, Bayesian approaches, dimensionality reduction, clustering, classification) for the specific questions that cancer genomics data analysis poses, distinguishing statistically robust from spurious findings in high-dimensional tumour genomics data where the curse of dimensionality, batch effects, and tumour heterogeneity create specific analytical challenges that general statistical methods must be carefully adapted to address
- Contribute to the systems biology integration of multi-omic tumour data — applying network analysis, pathway enrichment, regulatory network inference, and the specific computational systems biology methods that Alacris Theranostics uses to integrate genomic, transcriptomic, and epigenomic tumour data into the comprehensive disease models that support more precise treatment prediction than individual biomarker analysis alone can provide
Clinical Translation, Team Collaboration & Scientific Communication
- Translate bioinformatics insights into diagnostically actionable findings — working with molecular biologists and clinical partners to interpret NGS analysis outputs in the context of specific patient tumour profiles, identifying the genomic alterations, expression patterns, and molecular characteristics that are most clinically relevant for treatment decision support, and communicating analytical findings in the clear, clinically framed language that oncologists and clinical researchers need to act on bioinformatics results confidently
- Collaborate with bioinformaticians, molecular biologists, and software engineers in the Alacris Theranostics multidisciplinary team — contributing computational biology expertise to joint pipeline development projects, engaging productively with the wet-lab molecular biology team’s experimental design and quality control questions, and working with the software engineering team to integrate bioinformatics analysis outputs into Alacris Theranostics’s diagnostic reporting systems
- Maintain proactive approach to learning and developing new skills — staying current with the rapidly evolving NGS technology landscape, new computational methods for cancer genomics data analysis, and new precision oncology evidence that broadens the clinical relevance and diagnostic capability of Alacris Theranostics’s bioinformatics analysis platform
Requirements & Application
- Excellent programming skills in R and Python — demonstrated through research projects, publications, or professional bioinformatics experience that shows production-level bioinformatics code development rather than only basic scripting
- Proven expertise in NGS data analysis — with a demonstrable track record of processing and analysing at least some of the specified modalities (RNA-Seq, WES, WGS, single-cell) from tumour or clinically relevant samples
- Solid foundation in human molecular genetics — providing the biological knowledge context that makes NGS data interpretation clinically meaningful rather than purely computational
- Knowledge of statistics and high-dimensional data analysis — the quantitative rigour that distinguishes reliable bioinformatics findings from computationally impressive but statistically compromised results
- Genuine interest in precision oncology, proactive learning approach, and collaborative mindset — the personal qualities that make a bioinformatician genuinely productive and positively contributing in Alacris Theranostics’s clinical-scientific environment
About Alacris Theranostics & NGS Bioinformatics Careers in Berlin 2026
Alacris Theranostics GmbH‘s focus on personalised oncology — using the combination of NGS, advanced bioinformatics, and systems biology to transform scientific insights into cancer diagnostics and treatment decisions that are more precise than standard-of-care approaches — places it at the most clinically meaningful and scientifically stimulating frontier of computational oncology in Europe. For bioinformaticians and computational biologists who want their analytical work to matter — not only in the sense of producing interesting scientific findings, but in the more immediate and personal sense of informing treatment decisions for real cancer patients — Alacris Theranostics’s multidisciplinary clinical-scientific environment in Berlin provides exactly the professional context that makes computational oncology work genuinely fulfilling rather than only technically interesting. Berlin’s extraordinary life sciences ecosystem — anchored by Charité, MDC, BIH, Max Planck Institutes, and dozens of biotech companies — creates an unparalleled professional network and intellectual community for NGS bioinformaticians at every career stage. Applications close 15 April 2026. Apply immediately.
Your Career Growth Path: NGS Data Analyst (Bioinformatician) → Senior Bioinformatician → Lead Computational Biologist → Head of Bioinformatics → Director of Computational Oncology — a scientifically distinguished, clinically impactful, and professionally advancing computational cancer genomics career trajectory built at the personalised oncology frontier in one of Europe’s most vibrant biotech cities.
Who Should Apply?
- Experienced Bioinformaticians — Cancer Genomics (Post-Doc or Industry): With proven NGS data analysis track records across RNA-Seq, WES, WGS, or single-cell modalities, excellent R and Python skills, and publications demonstrating computational oncology or cancer genomics research contribution who want a clinical-translational bioinformatics role at Alacris Theranostics in Berlin
- Computational Biologists — Precision Medicine Transition: With strong R/Python bioinformatics programming and NGS analysis backgrounds in academic or research settings who want to transition to a clinical diagnostic biotech environment where their computational work directly informs cancer patient treatment decisions
- PhD Graduates — NGS Bioinformatics Specialization: Who completed doctoral research involving NGS data analysis (RNA-Seq, WES, WGS, or single-cell) in cancer or related biomedical contexts, have peer-reviewed publications demonstrating bioinformatics research output, and want a first post-PhD professional bioinformatics appointment in Berlin’s vibrant biotech sector
- Clinical Bioinformaticians — Oncology Background: With clinical bioinformatics experience in cancer genomics diagnostic pipelines — NGS variant analysis, tumour mutational burden, MSI, CNV, or immunogenomics — who want a scientific environment that combines pipeline development with systems biology integration and precision oncology application
- International Bioinformaticians — Berlin Relocation: From the UK, USA, Canada, India, China, or other countries with strong NGS cancer genomics bioinformatics track records who want to join Berlin’s outstanding life sciences and biotech ecosystem at a scientifically ambitious precision oncology company
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